| 1978 Draft | ||
| Round 1 | ||
| 1 | Milwaukee | Ozzie Smith |
| 2 | Bismarck | Lou Whitaker |
| 3 | Sacramento | Paul Molitor |
| 4 | Sacramento (via BAA) | Bob Welch |
| 5 | Kansas City | Willie Wilson |
| 6 | Columbus (via SLN) | Don Robinson |
| 7 | Reading (via COA) | Bob Horner |
| 8 | Columbus (via REA) | Rusty Staub |
| 9 | River City | Carney Lansford |
| 10 | Houston | Ken Oberkfell |
| 11 | St Paul | Scott Sanderson |
| 12 | Durham | Dwayne Murphy |
| 13 | Sioux Falls | Dan Ford |
| 14 | Hollywood | Mike LaCoss |
| 15 | Newark | Ron Hassey |
| 16 | Sioux Falls (via SEA) | Aurelio Lopez |
| 17 | Milwaukee (via PHN) | Rick Honeycutt |
| 18 | Sacramento (via HMA) | Larry McWilliams |
| 19 | California | Tom Paciorek |
| 20 | Memphis | Clint Hurdle |
| Round 2 | ||
| 21 | Sacramento | Jose Morales |
| 22 | Milwaukee | Steve McCatty |
| 23 | Bismarck | Steve Comer |
| 24 | Columbus (via BAA) | John Johnson |
| 25 | Kansas City | Gary Roenicke |
| 26 | California (via SLN) | Jerry Royster |
| 27 | Reading (via COA) | Damaso Garcia |
| 28 | Houston (via REA) | Ron Jackson |
| 29 | River City | Eric Rasmussen |
| 30 | Houston | Dave Frost |
| 31 | St Paul | Glenn Hubbard |
| 32 | Houston (via DUA) | Jerry White |
| 33 | Columbus (via SFA) | Willie Montanez |
| 34 | Hollywood | Kip Young |
| 35 | Newark | Junior Kennedy |
| 36 | Seattle | Sid Monge |
| 37 | Philadelphia | No pick - Overusage |
| 38 | Baltimore (via HMA) | Steve Mingori |
| 39 | California | Silvio Martinez |
| 40 | Newark (via MPA) | Bernie Carbo |
| Round 3 | ||
| 41 | Sacramento | Charlie Moore |
| 42 | Milwaukee | Shane Rawley |
| 43 | Bismarck | U.L. Washington |
| 44 | Memphis (via SLN/BAA) | Skip Lockwood |
| 45 | Kansas City | No pick - Overusage |
| 46 | Columbus (via SLN) | Chris Speier |
| 47 | Reading (via COA) | Denny Walling |
| 48 | Columbus (via REA) | Mark Lee |
| 49 | River City | Tom Burgmeier |
| 50 | Kansas City (via HON) | Steve Trout |
| 51 | St Louis (via SPN) | Mike Lum |
| 52 | Durham | Bo Diaz |
| 53 | Sioux Falls | No pick - Overusage |
| 54 | Hollywood | Kevin Kobel |
| 55 | Newark | John D'Acquisto |
| 56 | Durham (via SFA/SEA) | Byron McLaughlin |
| 57 | Philadelphia | Tim Stoddard |
| 58 | Philadelphia (via HMA) | Tom Hausman |
| 59 | California | Jim Morrison |
| 60 | Memphis | Rawly Eastwick |
| Round 4 | ||
| 61 | Sacramento | Don Aase |
| 62 | Milwaukee | Mike Heath |
| 63 | Bismarck | Craig Reynolds |
| 64 | Baltimore | Tom Dixon |
| 65 | Kansas City | Steve Renko |
| 66 | St Louis | Bruce Bochy |
| 67 | Columbus | Dale Murray |
| 68 | Reading | Merv Rettenmund |
| 69 | River City | Greg Pryor |
| 70 | Reading (via HON) | Bob Randall |
| 71 | St Paul | Dave Chalk |
| 72 | Milwaukee (via DUA) | Barry Bonnell |
| 73 | Bismarck (via SFA) | Victor Cruz |
| 74 | Hollywood | Roger Erickson |
| 75 | Newark | Bob Beall |
| 76 | Baltimore (via SEA) | Mike Squires |
| 77 | Baltimore (via SFA/PHN) | Rusty Torres |
| 78 | Milwaukee (via HMA) | Dan Meyer |
| 79 | California | Paul Hartzell |
| 80 | Memphis | Steve Braun |
| Round 5 | ||
| 81 | Sacramento | Mike Cubbage |
| 82 | Milwaukee | Alan Bannister |
| 83 | Bismarck | Jim Wohlford |
| 84 | Homestead (via SLN/BAA) | Mike Proly |
| 85 | Kansas City | Jim Beattie |
| 86 | St Louis | Mickey Lolich |
| 87 | Reading (via COA) | Roy White |
| 88 | Columbus (via REA) | Jim Essian |
| 89 | River City | Derrell Thomas |
| 90 | Milwaukee (via REA/HON) | Andy Hassler |
| 91 | St Paul | Ken Brett |
| 92 | Durham | Bombo Rivera |
| 93 | St Louis (via SFA) | Jay Alou |
| 94 | Hollywood | Aurelio Rodriguez |
| 95 | Newark | Bobby Valentine |
| 96 | Seattle | Jeff Newman |
| 97 | Homestead (via PHN) | Ross Baumgarten |
| 98 | Homestead | Rick Auerbach |
| 99 | California | Mickey Stanley |
| 100 | Memphis | Paul Reuschel |
| Round 6 | ||
| 101 | Sacramento | Donnie Moore |
| 102 | Durham (via MLN) | Willie Upshaw |
| 103 | Bismarck | Mick Kelleher |
| 104 | Baltimore | Hal Dues |
| 105 | Kansas City | Jack Billingham |
| 106 | St Louis | Tucker Ashford |
| 107 | Columbus | Don Hood |
| 108 | Reading | Rob Andrews |
| 109 | River City | Dave Lemanczyk |
| 110 | Houston | Rafael Landestoy |
| 111 | St Paul | Brian Asselstine |
| 112 | Columbus (via DUA) | Hosken Powell |
| 113 | Sioux Falls | Bruce Benedict |
| 114 | Hollywood | Bob Robertson |
| 115 | Newark | Bud Harrelson |
| 116 | Seattle | Mike Paxton |
| 117 | Milwaukee (via PHN) | John Curtis |
| 118 | Homestead | Dennis Kinney |
| 119 | California | Willie McCovey |
| 120 | Durham (via MPA) | Lenny Randle |
| Round 7 | ||
| 121 | Sacramento | Stan Bahnsen |
| 122 | Milwaukee | Dave Revering |
| 123 | Bismarck | Rich Hinton |
| 124 | Baltimore | Steve Skaggs |
| 125 | Kansas City | Tom Veryzer |
| 126 | Durham (via SLN) | Scot Thompson |
| 127 | Reading (via COA) | Bob Molinaro |
| 128 | Columbus (via REA) | Rod Gilbreath |
| 129 | River City | Paul Moskau |
| 130 | Houston | Tom Murphy |
| 131 | St Paul | Jack Kucek |
| 132 | Bismarck (via DUA) | Dan Goodwin |
| 133 | Sioux Falls | Randy Lerch |
| 134 | Hollywood | Pete Lacock |
| 135 | Newark | Tim Blackwell |
| 136 | Seattle | Dan Norman |
| 137 | St Paul (via PHN) | Mike Phillips |
| 138 | Homestead | George Frazier |
| 139 | California | Mike Colburn |
| 140 | Memphis | Jeff Holly |
| Round 8 | ||
| 141 | Sacramento | Dane Iorg |
| 142 | Philadelphia (via MLN) | Dave Ford |
| 143 | Bismarck | Rowland Office |
| 144 | Baltimore | Larry Harlow |
| 145 | Kansas City | Rick Bosettii |
| 146 | St Louis | Bert Campaneris |
| 147 | Columbus | Kevin Pasley |
| 148 | Reading | Rich Gale |
| 149 | River City | Mike Edwards |
| 150 | Houston | Paul Dade |
| 151 | St Paul | Jerry Morales |
| 152 | Baltimore (via DUA) | Dave McKay |
| 153 | Sioux Falls | Jim Wright |
| 154 | Hollywood | Dave Johnson |
| 155 | Newark | Larry Wolfe |
| 156 | Seattle | Sam Ewing |
| 157 | Homestead (via PHN) | Taylor Duncan |
| 158 | Homestead | Pedro Borbon |
| 159 | California | Tom House |
| 160 | Memphis | Vic Davalillo |
| Round 9 | ||
| 161 | Sacramento | Kiko Garcia |
| 162 | Philadelphia (via MLN) | Craig Kusick |
| 163 | Bismarck | Ray Burris |
| 164 | Baltimore | Jim Kaat |
| 165 | Kansas City | Bill Naharodny |
| 166 | St Louis | Tom Heintzelman |
| 167 | Reading (via COA) | Lee May |
| 168 | Columbus (via REA) | Marc Hill |
| 169 | River City | Paul Lindblad |
| 170 | Houston | Dave Bergman |
| 171 | St Paul | Manny Sanguillen |
| 172 | St Louis (via DUA) | Frank Lacorte |
| 173 | Sioux Falls | Rick Williams |
| 174 | Hollywood | Dick Davis |
| 175 | Newark | Henry Cruz |
| 176 | Seattle | Wayne Cage |
| 177 | Philadelphia | Dave Geisel |
| 178 | Homestead | Willie Norwood |
| 179 | California | Roger Freed |
| 180 | Memphis | Gary Serum |
| Round 10 | ||
| 181 | Sacramento | Dale Berra |
| 182 | Milwaukee | Buck Martinez |
| 183 | Bismarck | Steve Swisher |
| 184 | Baltimore | Dan Briggs |
| 185 | Kansas City | Jose Cardenal |
| 186 | St Louis | Lou Brock |
| 187 | Reading | Pat Putnam |
| 188 | River City | Rick Sweet |
| 189 | Houston | John Sutton |
| 190 | St Paul | Thad Bosley |
| 191 | Durham | Jerry Augustine |
| 192 | Sioux Falls | Larry Milbourne |
| 193 | Hollywood | Johnnie Lemaster |
| 194 | Newark | Bob Myrick |
| 195 | Seattle | John Ellis |
| 196 | Homestead | Jim Dwyer |
| 197 | California | Lerrin Lagrow |
| 198 | Memphis | Wilbur Howard |
| Round 11 | ||
| 199 | Sacramento | Alan Wirth |
| 200 | Milwaukee | Tom Griffin |
| 201 | Kansas City | Ralph Garr |
| 202 | St Louis | Tommy Boggs |
| 203 | River City | Al Fitzmorris |
| 204 | Houston | Ron Schueler |
| 205 | St Paul | David Clyde |
| 206 | Durham | Joe Wallis |
| 207 | Sioux Falls | Larry Biittner |
| 208 | Hollywood | Larry Cox |
| 209 | Newark | Doug Ault |
| 210 | Seattle | Roy Thomas |
| 211 | Philadelphia | Terry Crowley |
| 212 | Homestead | Jack Brohamer |
| 213 | California | Joe Coleman |
| 214 | Memphis | Phil Mankowski |
| Round 12 | ||
| 215 | Milwaukee | Glenn Burke |
| 216 | Kansas City | Jesse Jefferson |
| 217 | River City | Tom Spencer |
| 218 | Houston | Jay Johnstone |
| 219 | St Paul | Mike Tyson |
| 220 | Durham | Tim Johnson |
| 221 | Sioux Falls | Bill Stein |
| 222 | Hollywood | Ted Martinez |
| 223 | Seattle | Ron Blomberg |
| 224 | Philadelphia | Broderick Perkins |
| 225 | California | Tony Solaita |
| 226 | Memphis | John Hale |
| Round 13 | ||
| 227 | Houston | Steve Brye |
| 228 | Sioux Falls | Mickey Mahler |
| 229 | Philadelphia | Pete Broberg |
| 230 | Memphis | Dave Rader |
| Round 14 | ||
| 231 | Sioux Falls | Dave Hamilton |
| 232 | Philadelphia | Preston Hanna |
| 233 | Memphis | Bobby Thompson |
| Round 15 | ||
| 234 | Sioux Falls | Steve Burke |
| 235 | Philadelphia | Rich Wortham |
| Round 16 | ||
| 236 | Sioux Falls | Gene Clines |
| 237 | Philadelphia | Paul Mitchell |
| Round 17 | ||
| 238 | Sioux Falls | Darrell Jackson |
| 239 | Philadelphia | Andy Replogle |
| Round 18 | ||
| 240 | Sioux Falls | Mike Jorgensen |
| 241 | Philadelphia | Johnny Oates |
| Round 19 | ||
| 242 | Philadelphia | Kurt Bevacqua |