| 1980 Draft | ||
| Round 1 | ||
| 1 | Oakland | Lee Smith |
| 2 | Kansas City | Harold Baines |
| 3 | New York | Bill Gullickson |
| 4 | Sacramento | Dave Smith |
| 5 | Durham | Fernando Valenzuela |
| 6 | River City | Tom Herr |
| 7 | St Paul | Britt Burns |
| 8 | New York (via SLN) | Mike Scioscia |
| 9 | Niagara Falls | Lonnie Smith |
| 10 | Houston | Leon Durham |
| 11 | Minneapolis | Bruce Hurst |
| 12 | Oakland (via BAA) | Lamarr Hoyt |
| 13 | California | Al Holland |
| 14 | Bismarck | Doug Corbett |
| 15 | Newark | Ron Oester |
| 16 | Durham (via NFA/SFA) | Steve Howe |
| 17 | Hollywood | Dan Driessen |
| 18 | Sacramento (via REA) | Mookie Wilson |
| 19 | Hollywood (via HMA) | Hubie Brooks |
| 20 | Sacramento (via PHN) | Gary Lucas |
| Round 2 | ||
| 21 | Kansas City | Ruppert Jones |
| 22 | Oakland | Charlie Lea |
| 23 | Durham (via NYA) | Lloyd Moseby |
| 24 | Sacramento | Juan Beniquez |
| 25 | Durham | Joe Charboneau |
| 26 | River City | Barry Bonnell |
| 27 | St Paul | Larry Christenson |
| 28 | Sioux Falls (via SLN) | Charlie Liebrandt |
| 29 | Niagara Falls | Joe Price |
| 30 | Houston | Rod Scurry |
| 31 | Minneapolis | Wally Backman |
| 32 | Kansas City (via BAA) | Luis Leal |
| 33 | California | No pick - Overusage |
| 34 | Bismarck | Dave Stapleton |
| 35 | Newark | Bob Ojeda |
| 36 | St Paul (via SFA) | Eddie Solomon |
| 37 | Hollywood | No pick - Overusage |
| 38 | New York (via REA) | Rudy Law |
| 39 | Niagara Falls (via HMA) | Bill Travers |
| 40 | Philadelphia | Ron Reed |
| Round 3 | ||
| 41 | Kansas City | Rick Monday |
| 42 | Oakland | Tim Blackwell |
| 43 | New York | Enos Cabell |
| 44 | Sacramento | Broderick Perkins |
| 45 | St Louis (via DUA) | Gary Ward |
| 46 | River City | Denny Walling |
| 47 | St Paul | Marty Bystrom |
| 48 | St Louis | Gary Allenson |
| 49 | Niagara Falls | Dave Lapoint |
| 50 | Houston | Rick Peters |
| 51 | Minneapolis | Steve Trout |
| 52 | Kansas City (via BAA) | Dan Graham |
| 53 | California | Larry Sorensen |
| 54 | Bismarck | Glenn Abbott |
| 55 | Newark | Alan Bannister |
| 56 | Durham (via SFA) | Mike Squires |
| 57 | Kansas City (via HWN) | Steve Mura |
| 58 | Hollywood (via REA) | Rodney Scott |
| 59 | Sacramento (via HOA) | Ross Baumgarten |
| 60 | Reading (via SRN/PHN) | Glenn Hoffman |